Investigators from Brigham and Women’s Hospital (BWH) and the Harvard Stem Cell Institute (HSCI) may have discovered a way to kill tumor cells that have metastasized to the brain.
The team has developed cancer-killing viruses that can deliver stem cells via the carotid artery, and applied them to metastatic tumors in the brains of clinically relevant mouse models. The elimination of metastatic skin cancer cells from the brains of these preclinical models resulted in prolonged survival, the investigators report. The study, published online this week in the journal PNAS,also describes a strategy of combining this therapy with immune checkpoint inhibitors.
Click here to read the full article by BWH/HSCI Communications and the Harvard Gazette.